 | 教授 博士生导师 性别: 男
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个人简介
邓诣群，1975年出生，博士。致力于动物蛋白质（酶）的功能、结构及调控机理研究，重点关注真菌毒素等外源化合物在动物体内的分子毒理和代谢转化机制。入选国家“万人计划”科技创新领军人才（2016年）、广东省“珠江学者”特聘教授（2009年）、教育部“新世纪优秀人才支持计划”（2008年）；兼任中国生物化学与分子生物学会理事、广东省农业生物蛋白质功能与调控重点实验室主任。
主持国家重点基础研究发展计划（973）课题、NSFC-广东联合基金重点项目、广东省自然科学基金研究团队项目等；以通讯/共同通讯作者身份在 Cell Death and Differentiation, Nucleic Acids Research和Oncogene 等期刊发表47篇论文（1篇获F1000推荐）；授权5项国家发明专利；荣获全国师德标兵、教育部霍英东青年教师奖（二等奖）、广东省丁颖科技奖等。
工作经历
2007.12 ~ 至今 js4399金沙线 教授
2007.07 ~ 2007.12 美国康奈尔大学医学院生化系 Instructor
2002.09 ~ 2007.06 美国康奈尔大学医学院生化系 Postdoctoral Fellow
2000.08 ~ 2002.02 香港科技大学生化系 Visiting Scholar
学习经历
| 学位 | 学历 | 学科门类 | 专业 | 毕业学校 | 类型 | 入学时间 | 毕业时间 |
|---|---|---|---|---|---|---|---|
博士 | 博士 研究生 | 医学 | 生化与分子 生物学 | 中山大学中山 医学院 | 全日制 | 1999-09 | 2002-06 |
硕士 | 硕士 研究生 | 医学 | 生化与分子 生物学 | 中山医科大学 | 全日制 | 1996-09 | 1999-06 |
学士 | 大学本科 | 医学 | 临床医学 | 皖南医学院 | 全日制 | 1991-09 | 1996-06 |
研究方向
1. 真菌毒素的分子毒理和代谢转化
2. 动物蛋白质（酶）功能、结构与调控
代表性论文
Selected publications related to current work (*corresponding author ):
Research articles:
Han Qiao, Tianqing Jiang, Peiqiang Mu, Xiaoxuan Chen, Xianhui Wen, Zhangsheng Hu, Shulin Tang, Jikai Wen*, Yiqun Deng*. Cell fate determined by the activation balance between PKR and SPHK1. Cell Death and Differentiation. 2020 Aug 15. doi: 10.1038/s41418-020-00608-8.
Boyan Huang#, Peiqiang Mu#, Yan Yu, Wenya Zhu, Tianqing Jiang, Rong Deng, Gongkan Feng, Jikai Wen, Xiaofeng Zhu*, Yiqun Deng* Inhibition of EZH2 and Activation of ERRγ Synergistically Suppresses Gastric Cancer by Inhibiting FOXM1 Signaling Pathway. Gastric Cancer. 2020 Jun 11. doi: 10.1007/s10120-020-01097-x.(# co-first author)
Shulin Tang, Yurong Zhao, Xirong He, Jiahui Zhu, Shuang Chen,Jikai Wen *, Yiqun Deng*, Identification of NOVA family proteins as novel β-catenin RNA-binding proteins that promote epithelial-mesenchymal transition. RNA Biology. 2020 Mar; DOI: 10.1080/15476286.2020.1734372
Shulin Tang, Shuang Chen, Boyan Huang, Jun Jiang, Jikai Wen, Yiqun Deng*. Deoxynivalenol induces inhibition of cell proliferation via the Wnt/beta-catenin signaling pathway. Biochemical Pharmacology. 2019 Aug; 166:12-22. (F1000★★)
Haoran Jiang, Jun Wu, Feiyong Zhang, Jikai Wen, Jun Jiang, Yiqun Deng*. The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1. Biochemical Pharmacology. 2018 Oct; 156: 177-185.
Xiaoming Li, Peiqiang Mu, Han Qiao, Jikai Wen, Yiqun Deng*. JNK-AKT-NF-κB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells. Biochemical Pharmacology. 2018 Oct; 156: 120-134.
Jun Jiang, Shulin Tang, Jianhong Xia, Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y. Huen, Yiqun Deng*. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 2018 May; 37(22): 2992-3005.
Xin Liu, Jikai Wen, Ruohong Chen, Tingting Zhang, Jun Jiang, Yiqun Deng*. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y. Biochimica et Biophysica Acta-General Subjects. 2016 Oct; 1860(10): 2191-2201.
Linfeng Dong, Qingmei Chen, Xin Liu, Jikai Wen, Jun Jiang, Yiqun Deng*. Role of specificity protein 1, hepatocyte nuclear factor 1α, and pregnane x receptor in the basal and rifampicin-induced transcriptional regulation of porcine cytochrome P450 3A46. Drug Metabolism and Disposition. 2015 Oct; 43(10):1441-1449.
Qi Yang, Shulin Tang, Linfeng Dong, Qingmei Chen, Xin Liu, Jun Jiang, Yiqun Deng*. Transcriptional regulation of chicken cytochrome P450 2D49 (CYP2D49) basal expression by CCAAT/enhancer-binding protein α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α). FEBS Journal.2014 Mar; 281(5): 1379-1392.
Peiqiang Mu, Ming Xu, Lei Zhang, Kaixin Wu, Jun Wu, Jun Jiang, Qingmei Chen, Lijuan Wang, Xianqing Tang, Yiqun Deng*. Proteomic changes in chicken primary hepatocytes exposed to T-2 toxin are associated with oxidative stress and mitochondrial enhancement. Proteomics. 2013 Nov; 13(21): 3175-3188.
Jun Wu, Weiying Xu, Caihui Zhang, Qing Chang, Xianqing Tang, Kangbai Li, Yiqun Deng*. Trp266 determines the binding specificity of a porcine aflatoxin B1 aldehyde reductase for aflatoxin B1-dialdehyde. Biochemical Pharmacology. 2013 Nov; 86(9): 1357-1365.
Shirley M.H. Sy#, Jun Jiang#, Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*. The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks. Nucleic Acids Research. 2013 Oct; 41(18): 8572-8580.(#co-first author)
Jie Chen, Wanjuan Feng, Jun Jiang, Yiqun Deng*, Michael S.Y. Huen*. Ring finger protein RNF169 antagonises the ubiquitin-dependent signaling cascade at sites of DNA damage. Journal of Biological Chemistry. 2012 Aug; 287(33): 27715-27722.
Jianshe Wang#, Jun Jiang#, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*, Jiayin Dai*. Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & Cellular Proteomics. 2011 Sep; 10(9): M111.008748. (#co-first author)
Shirley M.H. Sy#, Jun Jiang#, Sui-sui Dong, Gabriel Tsz-Mei Lok, Jun Wu, Hua Cai, Enoch S.L. Yeung, Jun Huang, Junjie Chen, Yiqun Deng*, Michael S.Y. Huen*. Critical roles of ring finger protein RNF8 in replication stress responses. Journal of Biological Chemistry.2011 Jun; 286(25): 22355-22361.(#co-first author)
Invited review:
Jikai Wen, Peiqiang Mu, Yiqun Deng*. Mycotoxins: cytotoxicity and biotransformation in animal cells. Toxicology Research. 2016 Mar; 5(2): 377-387.
(The official journal of The British Toxicology Society and The Chinese Society of Toxicology)
Selected earlier publications:
Yiqun Deng, Jie Liu, Qi Zheng, Qunnu Li, Neville R. Kallenbach, Min Lu. A heterospecific leucine zipper tetramer. Chemistry & Biology. 2008 Sep;15(9): 908-919.(Current Journal Name: Cell Chemical Biology)
Yiqun Deng, Jie Liu, Qi Zheng, Wei Yong, Min Lu. Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein.Structure. 2006 May; 14(5): 889-899.
Yiqun Deng, Jie Liu, Qi Zheng, David Eliezer, Neville R. Kallenbach, Min Lu. Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure. 2006 Feb; 14(2): 247-255.
Jiayin Dai, Jie Liu, Yiqun Deng, Thomas M. Smith, Min Lu. Structure and protein design of a human platelet function inhibitor.Cell. 2004 Mar; 116(5): 649-659. (Featured Article)
1. 发明名称：伊格尔兹氏菌Eggerthella sp. DII -9在降解呕吐毒素中的应用
发明人：邓诣群、母培强、高小娟、陈庆梅、文继开
专利号：ZL 2016 1 0785036.4
授权公告日：2018年3月6日
2. 发明名称：一株高效降解呕吐毒素的伊格尔兹氏菌Eggerthella sp. DII-9
发明人：邓诣群；高小娟；母培强；陈庆梅；文继开
专利号：ZL 2016 1 0785205.4
授权公告日：2017年7月11日
国家“万人计划”科技创新领军人才（2016年~）
科技部创新人才推进计划“中青年科技创新领军人才”（2014年~）
广东省高等学校特聘教授“珠江学者”（2009年~2014年）
教育部“新世纪优秀人才支持计划”（2008年~2011年）
荣誉奖励
全国师德标兵、广东省师德标兵（2015年）
南粤优秀教师（2012年）
第四届中国侨界贡献奖（创新人才）（2012年）
教育部霍英东教育基金会第十三届高等院校青年教师奖（二等奖）（2012年）
第十一届广东省丁颖科技奖（2012年）
第十三届广东青年五四奖章（2011年）
学术兼职
广东省农业生物蛋白质功能与调控重点实验室 主任
中国生物化学与分子生物学会 理事
广东省生物化学与分子生物学会 副理事长
Society of Toxicology（美国毒理学会） Full Member
Frontiers in Pharmacology Guest Associate Editor
Curriculum Vitae
Name: Yiqun DENG
E-mail: yqdeng@scau.edu.cn
Address:
College of Life Sciences
South China Agricultural University
483 Wushan Road, Tianhe District
Guangzhou, Guangdong 510642
People's Republic of China
PRESENT ACADEMIC POSITION
2007.12 -
Professor of Biochemistry and Molecular Biology,
College of Life Sciences, South China Agricultural University
EDUCATION
Doctor,Biochemistry and Molecular Biology, Sun Yat-sen University, China, 2002
Master, Biochemistry and Molecular Biology, Zhongshan University of Medical Sciences, China, 1999
Bachelor, Clinical Medicine, Wannan Medical College, China, 1996
ACADEMIC QUALIFICATIONS
2007.7-2007.12
Instructor of Biochemistry
Weill Medical College of Cornell University, New York
2002.9-2007.6
Postdoctoral Fellow
Department of Biochemistry
Weill Medical College of Cornell University, New York
2000.8-2002.2
Visiting Scholar
Department of Biochemistry
Hong Kong University of Science & Technology, Hong Kong
RESEARCH INTEREST
The cytotoxicity of mycotoxins in animals.
The molecular mechanisms of metabolism for xenobiotics, especially mycotoxins.
The function, expression and regulation of key metabolic enzymes in animals, e.g. Cytochrome P450.
