|
| ||||
教育经历
2001/09-2008/02，美国纽约城市大学研究生院与大学中心（CUNY-Graduate School and University Center），哲学博士，生物化学专业
1998/09-2001/07，中山大学，理学硕士，遗传学专业
1994/09-1998/07，中山大学，理学学士，微生物学专业
科研与学术工作经历
2015/10至今，学院，js4399金沙线，教授；
2014/01-2015/09，美国威斯康星大学麦迪逊分校，遗传系，助理研究员；
2009/01-2013/12，美国威斯康星大学麦迪逊分校，遗传系，博士后；
研究领域
1. 主要以拟南芥为材料，通过遗传学、细胞生物学及多维组学解析植物细胞自噬的功能和调控机制；
2. 以玉米为材料，重点研究细胞自噬在产量、品质和逆境适应性等重要农艺性状形成中的生物学功能；
3. 改造细胞自噬衔接蛋白，研发适用于植物细胞的靶向降解技术。
科研项目
1. 国家自然科学基金面上项目，拟南芥ABA受体通过选择性细胞自噬降解的分子机制研究，2020/01-2023/12，在研，主持。
2. 国家自然科学基金面上项目，细胞自噬在玉米胚乳发育过程中的作用及调控机制的研究，2018/01-2021/12，结题，主持。
3. 广东省自然科学基金项目，拟南芥抗真菌毒素脱氧雪腐镰刀菌烯醇相关基因的鉴定与功能分析，2021/01-2023/12，在研，主持。
4. 中山大学有害生物控制与资源利用国家重点实验室开放课题，2021/01-2023/12，在研，主持。
5. 广东省自然科学基金项目，ATG8互作蛋白FYVE2a/b调控植物细胞自噬的分子机制研究，2018/05-2021/04，结题，参加。
6. 学院丁颖人才重点培养对象项目，2016始，在研，主持。
7. 学院高层次引进人才科研启动项目，2015/10始，在研，主持。
发表论文
1. Luo N, Shang D, Tang Z, Mai J, Huang X, Tao LZ, Liu L, Gao C, Qian Y, Xie Q*, Li F* (2023). Engineered AIM-based selective autophagy to degrade proteins and organelles in planta. New Phytol. 237(2):684-697. doi: 10.1111/nph.18557. (*Co-corresponding author)
2. 黄晓，邓桂玲，李发强* (2022) 基于细胞自噬的靶向降解技术及在植物研究中的应用前景，学院学报，43(6): 97-106.
3. Zheng C, Yu Y, Deng G, Li H, Li F* (2022). Network and Evolutionary Analysis Reveals Candidate Genes of Membrane Trafficking Involved in Maize Seed Development and Immune Response. Front Plant Sci. 4, 13:883961.
4. Bao Y*, Gao C*, Avin-Wittenberg T*, Zhou J*, Li F* (2022). Editorial: Molecular Perspectives for Plant Autophagy Regulation. Front Plant Sci. 13, 967916 (*Co-corresponding author).
5. Zheng P, Zheng C, Otegui MS*, and Li F* (2022). Endomembrane mediated trafficking of seed storage proteins: from Arabidopsis to cereal crops. J. Exp. Bot. 73, 1312-1326 (*Co-corresponding author).
6. Kim JH, Lee HN, Huang X, Jung H, Otegui MS, Li F*, and Chung T* (2022). FYVE2, a phosphatidylinositol 3-phosphate effector, interacts with the COPII machinery to control autophagosome formation in Arabidopsis. Plant Cell. 34, 351-373 (*Co-corresponding author).
7. Xiao Z, Yang C, Liu C, Yang L, Yang S, Zhou J, Li F, Jiang L, Xiao S, Gao C*, Shen WJ* (2020). SINAT E3 ligases regulate the stability of the ESCRT component FREE1 in response to iron deficiency in plants. Integr Plant Biol. 62:1399-1417.
8. Yang C, Luo M, Zhuang X, Li F, Gao C* (2020). Transcriptional and epigenetic regulation of autophagy in plants. Trends Genet. 36:676-688.
9. McLoughlin F, Marshall RS, Ding X, Chatt EC, Kirkpatrick LD, Augustine RC, Li F, Otegui MS, Vierstra RD* (2020). Autophagy plays prominent roles in amino acid, nucleotide, and carbohydrate metabolism during fixed-carbon starvation in Maize. Plant Cell. 32:2699-2724.
10. Yang C, Shen W, Yang L, Sun Y, Li X, Lai M, Wei J, Wang C, Xu Y, Li F, Liang S, Yang C, Zhong S, Luo M, Gao C* (2020). HY5-HDA9 module transcriptionally regulates plant autophagy in response to light-to-dark conversion and nitrogen starvation. Mol Plant. 13:515-531.
11. Huang X, Zheng C, Liu F, Yang C, Zheng P, Lu X, Tian J, Chung T, Otegui MS, Xiao S, Gao C, Vierstra RD*, and Li F* (2019). Genetic analyses of the Arabidopsis ATG1 kinase complex reveal both kinase-dependent and independent autophagic routes during fixed-carbon starvation. Plant Cell. 31(12): 2973-2995, DOI: https://doi.org/10.1105/tpc.19.00066. (*Co-corresponding author, this article was evaluated by Faculty Opinions with a good rating.)
12. Gou W, Li X, Guo S, Liu Y, Li F, and Xie Q* (2019). Autophagy in plant: a new orchestrator in the regulation of the phytohormones homeostasis. Int. J. Mol. Sci. 20(12), 2900.
13. Liu F, Marshall RS, and Li F* (2018). Understanding and exploiting the roles of autophagy in plants through multi-omics approaches. Plant Sci. 274, 146-152.
14. McLoughlin F, Augustine RC, Marshall RS, Li F, Kirkpatrick, L.D., Otegui, MS, and Vierstra, RD* (2018). Maize multi-omics reveal roles for autophagic recycling in proteome remodelling and lipid turnover. Nat. Plants 4, 1056-1070.
15. Qi H, Xia FN, Xie LJ, Yu LJ, Chen QF, Zhuang XH, Wang Q, Li F, Jiang L, Xie Q, and Xiao S* (2017). TRAF-family proteins regulate autophagy dynamics by modulating AUTOPHAGY PROTEIN6 stability in Arabidopsis. Plant Cell. 29:890-911.
16. Chen L, Li F*, and Xiao S* (2017). Analysis of plant autophagy. Methods Mol Biol 1662, 267-280. (*Co-corresponding author)
17. 黄晓, 李发强* (2016). 细胞自噬在植物细胞程序性死亡中的作用. 植物学报 51, 859-862.
18. Klionsky DJ*, and multiple authors including Li F (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-222.
19. Li F, Chung T, Pennington JG, Federico ML, Kaeppler HF, Kaeppler SM, Otegui MS, and Vierstra RD* (2015). Autophagic recycling plays a central role in maize nitrogen remobilization. Plant Cell 27, 1389-1408.
20. Marshall RS, Li F, Gemperline DC, Book AJ, and Vierstra RD* (2015). Autophagic degradation of the 26S proteasome is mediated by the dual ATG8/Ubiquitin receptor RPN10 in Arabidopsis. Mol. Cell 58, 1053-1066.
21. Spitzer C, Li F, Buono R, Roschzttardtz H, Chung T, Zhang M, Osteryoung KW, Vierstra RD, and Otegui MS* (2015). The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis. Plant Cell. 27:391-402
22. Li F, Chung T, and Vierstra RD* (2014). AUTOPHAGY-RELATED11 plays a critical role in general autophagy- and senescence-induced mitophagy in Arabidopsis. Plant Cell 26, 788-807.
23. Li F, and Vierstra RD* (2014). Arabidopsis ATG11, a scaffold that links the ATG1-ATG13 kinase complex to general autophagy and selective mitophagy. Autophagy 10, 1466-1467.
24. Klionsky DJ*, and multiple authors including Li F (2012). Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544.
25. Li F, and Vierstra RD* (2012a). Autophagy: a multifaceted intracellular system for bulk and selective recycling. Trends Plant Sci. 17, 526-537.
26. Li F, and Vierstra RD* (2012b). Regulator and substrate: dual roles for the ATG1-ATG13 kinase complex during autophagic recycling in Arabidopsis. Autophagy 8, 982-984.
27. Suttangkakul A#, Li F#, Chung T, and Vierstra RD* (2011). The ATG1/ATG13 protein kinase complex is both a regulator and a target of autophagic recycling in Arabidopsis. Plant Cell 23, 3761-3779. (#Co-first author)
28. Chen Y#, Li F#, and Wurtzel ET* (2010). Isolation and characterization of the Z-ISO gene encoding a missing component of carotenoid biosynthesis in plants. Plant Physiol. 153, 66-79. (#Co-first author)
29. Li F, Tsfadia O, and Wurtzel ET* (2009). The phytoene synthase gene family in the Grasses: subfunctionalization provides tissue-specific control of carotenogenesis. Plant Signal Behav. 4, 208-211.
30. Li F, Vallabhaneni R, Yu J, Rocheford T, and Wurtzel ET* (2008b). The maize phytoene synthase gene family: overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant Physiol. 147, 1334-1346.
31. Li F, Vallabhaneni R, and Wurtzel ET* (2008a). PSY3, a new member of the phytoene synthase gene family conserved in the Poaceae and regulator of abiotic stress-induced root carotenogenesis. Plant Physiol. 146, 1333-1345.
32. Li F, Murillo C, and Wurtzel ET* (2007). Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. Plant Physiol. 144, 1181-1189.
33. Gallagher CE, Matthews PD, Li F, and Wurtzel ET* (2004). Gene duplication in the carotenoid biosynthetic pathway preceded evolution of the grasses. Plant Physiol. 135, 1776-1783.
教学活动
1. 承担《分子生物学》、《细胞生物学》等本科课程。
2. 指导本科生获得2021年iGEM全球总决赛金奖。
