STAFF
Peiqiang Mu
Associate professor, Director of Depatment of Biochemistry
Collegeof Life Sciences,
SouthChina Agricultural University,
Guangzhou,Guangdong 510642, China
Tel:+86-20-38604967 (O)
EDUCATION
Postdoc.,08/2011-06/2014, Biochemistry and Molecular Biology, College of Life Sciences, South China Agricultural University. Advisor, Yiqun Deng.
Ph.D., 09/2006-07/2011, Genetics, School of Life Sciences, Sun Yat-sen University. Advisor, Jinfa Wang.
B.Ag., 09/2002-07/2006, Sericultural Science and Biotechnology, College of Animal Sciences, South China Agricultural University.
PROFESSIONAL EXPERIENCE
1. 01/2018-present, Associate Professor, College of Life Sciences, South China Agricultural University.
2. 08/2021-10/2022, Visiting Scholar, Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge.
3. 05/2015-12/2017, Young Associate Professor (Special program for young outstanding researchers), College of Life Sciences, South China Agricultural University.
4. 07/2014-04/2015, Associate Research Fellow, College of Life Sciences, South China Agricultural University.
5. 10/2013-03/2014, Visiting Scholar, Department of Biology, Johns Hopkins University.
RESEARCH INTERESTS
1. Toxicology and metabolism of mycotoxins (Deoxynivalenol, T-2 toxin, etc.)
Mycotoxins are secondary metabolites produced by microfungi, including Fusarium, Penicillium, etc. Mycotoxins can exert acute, sub-acute and chronic toxicological effects to animals and humans. However, the toxicology and metabolism of many mycotoxins are still unclear. We are interested to understand the toxicology of mycotoxin at cellular and molecular level, especially its mechanisms underlying mitochondrial damage, DNA damage, histone modification changes, cell cycle alterations. We are also committed to identifying microbes and enzymes which can detoxify mycotoxins and applying them in animal feed industry.
SELECTED PUBLICATIONS
[1]Chongwen Guo, Jikai Wen, Yu Sun, Guoqiang Liang, Zijiao Wang,Lulu Pan,Jiarun Huang,Yuanxin Liao,Zeyuan Wang,Qingmei Chen,Peiqiang Mu*and Yiqun Deng.Pyrroloquinoline quinone production defines the ability of Devosia species to degrade deoxynivalenol. Food & Function, 2024, 15, 6134-6146.
[2]Ason C. Y. Chiang, Jan Ježek, Peiqiang Mu, Ying Di, Anna Klucnika, Martin Jabůrek, Petr Ježek & Hansong Ma.Two mitochondrial DNA polymorphisms modulate cardiolipin binding and lead to synthetic lethality. Nature Communications，2024; 15: 611.
[3]Anna Klucnika, Peiqiang Mu, Jan Jezek, Matthew McCormack, Ying Di, Charles R. Bradshaw, Hansong Ma; REC drives recombination to repair double-strand breaks in animal mtDNA. Journal of Cell Biology, 2023; 222 (1): e202201137.
[4]Boyan Huang#, Peiqiang Mu#, Yan Yu, Wenya Zhu, Tianqing Jiang, Rong Deng, Gongkan Feng, Jikai Wen, Xiaofeng Zhu, Yiqun Deng. Inhibition of EZH2 and activation of ERRγ synergistically suppresses gastric cancer by inhibiting FOXM1 signaling pathway. Gastric Cancer, 2021. 24(1):72-84.
[5]Haibin Mu#, Peiqiang Mu#, Wenya Zhu, Boyan Huang, Hui Li, Liping Yuan, Yiqun Deng.Low doses of deoxynivalenol inhibit the cell migration mediated by H3K27me3-targeted downregulation of TEM8 expression. Biochemical Pharmacology,2020. 175: 113897.
[6]Boyan Huang#, Qingmei Chen#, Lingling Wang, Xiaojuan Gao, Wenya Zhu, Peiqiang Mu*, Yiqun Deng*. Aflatoxin B1 induces neurotoxicity through reactive oxygen species generation, DNA damage, apoptosis, and s-phase cell cycle arrest. International Journal of Molecular Sciences. 2020; 21(18): E6517.
[7]Xiaojuan Gao#, Peiqiang Mu#, Xunhua Zhu, Xiaoxuan Chen, Shulin Tang, Yuting Wu, Xiang Miao, Xiaohan Wang, Jikai Wen, Yiqun Deng. Dual function of a novel bacterium, Slackia sp. D-G6: detoxifying deoxynivalenol and producing the natural estrogen analogue, equol. Toxins, 2020. 12(2): 85.
[8]Boyan Huang#, Peiqiang Mu#, Xiaoxuan Chen, Shulin Tang, Wenchu Ye, Wenya Zhu, and Yiqun Deng, Aflatoxin B-1 induces S phase arrest by upregulating the expression of p21 via MYC, PLK1 and PLD1.Biochemical Pharmacology, 2019. 166: 108-119.
[9]Xiaojuan Gao#, Peiqiang Mu#, Jikai Wen, Yu Sun, Qingmei Chen, and Yiqun Deng, Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp DII-9.Food and Chemical Toxicology, 2018. 112: 310-319.
[10]Peiqiang Mu, Ming Zheng, Ming Xu, Yuanming Zheng, Xianqing Tang, Yufan Wang, Kaixin Wu, Qingmei Chen, Lijuan Wang, and Yiqun Deng, N-Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by Porcine Aldehyde Oxidase SsAOX1.Drug Metabolism and Disposition, 2014. 42(4): 511-519.
[11]Peiqiang Mu, Ming Xu, Lei Zhang, Kaixin Wu, Jun Wu, Jun Jiang, Qingmei Chen, Lijuan Wang, Xianqing Tang, and Yiqun Deng, Proteomic changes in chicken primary hepatocytes exposed to T-2 toxin are associated with oxidative stress and mitochondrial enhancement.Proteomics, 2013. 13(21): 3175-3188.
[12]Peiqiang Mu, Dongru Feng, Jianbin Su, Yang Zhang, Jinran Dai, Honglei Jin, Bing Liu, Yanming He, Kangbiao Qi, Hongbin Wang, and Jinfa Wang, Cu2+ triggers reversible aggregation of a disordered His-rich dehydrin MpDhn12 from Musa paradisiaca. Journal of Biochemistry, 2011. 150(5): 491-499.