STAFF
Prof. Yiqun Deng
College of Life Sciences,
South China Agricultural University,
Guangzhou, Guangdong 510642, China
Tel: +86-20-38604967 (O)
E-mail: yqdeng@scau.edu.cn
Education
Ph.D., Biochemistry and Molecular Biology.
Sun Yat-sen University, China, 2002.
M.S., Biochemistry and Molecular Biology.
Zhongshan University of Medical Sciences, China, 1999.
B.S.Me, Clinical Medicine.
Wannan Medical College, China, 1996.
Professional Biography
2007.12-present, Professor, College of Life Sciences, South China Agricultural University, China
2007.7-2007.12, Instructor of Biochemistry, Weill Medical College of Cornell University, USA.
2002.9-2007.6, Postdoctoral Associate, Department of Biochemistry, Weill Medical College of Cornell University, USA.
2000.8-2002.2, Visiting Scholar, Department of Biochemistry, Hong Kong University of Science & Technology, Hong Kong, China.
Area of Expertise
The cytotoxicity of mycotoxins in animals.
The molecular mechanisms of metabolism for xenobiotics, especially mycotoxins.
The function, expression and regulation of key metabolic enzymes in animals, e.g. Cytochrome P450.
Selected Publications |
1. Shulin Tang, Yurong Zhao, Xirong He, Jiahui Zhu, Shuang Chen,Jikai Wen *, Yiqun Deng*, Identification of NOVA family proteins as novel β-catenin RNA-binding proteins that promote epithelial-mesenchymal transition. RNA Biology. 2020 Mar; 17(6): 881-891. 2. Shulin Tang, Shuang Chen, Boyan Huang, Jun Jiang, Jikai Wen, Yiqun Deng*. Deoxynivalenol induces inhibition of cell proliferation via the Wnt/beta-catenin signaling pathway. Biochemical Pharmacology. 2019 Aug; 166:12-22. (F1000★★) 3. Haoran Jiang, Jun Wu, Feiyong Zhang, Jikai Wen, Jun Jiang, Yiqun Deng*. The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1. Biochemical Pharmacology. 2018 Oct; 156: 177-185. 4. Xiaoming Li, Peiqiang Mu, Han Qiao, Jikai Wen, Yiqun Deng*. JNK-AKT-NF-κB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells. Biochemical Pharmacology. 2018 Oct; 156: 120-134. 5. Jun Jiang, Shulin Tang, Jianhong Xia, Jikai Wen, Shuang Chen, Xiaodong Shu, Michael S. Y. Huen, Yiqun Deng*. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling. Oncogene. 2018 May; 37(22): 2992-3005. 6. Xin Liu, Jikai Wen, Ruohong Chen, Tingting Zhang, Jun Jiang, Yiqun Deng*. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y. Biochimica et Biophysica Acta-General Subjects. 2016 Oct; 1860(10): 2191-2201. 7. Qi Yang, Shulin Tang, Linfeng Dong, Qingmei Chen, Xin Liu, Jun Jiang, Yiqun Deng*. Transcriptional regulation of chicken cytochrome P450 2D49 (CYP2D49) basal expression by CCAAT/enhancer-binding protein α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α). FEBS Journal.2014 Mar; 281(5): 1379-1392. 8. Jun Wu, Weiying Xu, Caihui Zhang, Qing Chang, Xianqing Tang, Kangbai Li, Yiqun Deng*. Trp266 determines the binding specificity of a porcine aflatoxin B1 aldehyde reductase for aflatoxin B1-dialdehyde. Biochemical Pharmacology. 2013 Nov; 86(9): 1357-1365. 9. Shirley M.H. Sy#, Jun Jiang#, Wai Sum O, Yiqun Deng*, Michael S.Y. Huen*. The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks. Nucleic Acids Research. 2013 Oct; 41(18): 8572-8580.(#co-first author) 10. Jianshe Wang#, Jun Jiang#, Hongxia Zhang, Junping Wang, Hua Cai, Cheng Li, Kangbai Li, Jing Liu, Xuejiang Guo, Guangxun Zou, Dazhi Wang, Yiqun Deng*, Jiayin Dai*. Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes. Molecular & Cellular Proteomics. 2011 Sep; 10(9): M111.008748. (#co-first author) |